Aplication of Smart Biomaterials for Cell Encapsulation

For long-term cell encapsulation, besides overcoming suffocation, how to promote blood vessel formation in and/or surrounding the implanted. Biomaterials are extremely challenging. As a new trend towards smart biomaterials, researchers are trying to design new encapsulating materials to control cell behavior by closely mimicking the natural in vivo cellular microenvironment, such as by providing the necessary signaling molecules, and biophysical and bioactive cues. In order to control neovasculature development, it s important to figure out which regulator factors and cell types affect the formation of blood vessels. Well studied angiogenesis stimulatory factors include fibroblast growth factor (bFGF), certain matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF). There are numerous cell types involved in vascular networks, such as vascular endothelial cells (VECs), smooth muscle cells (VSMCs) and mesenchymal stem cells (MSCs). Based on this knowledge of vascularization, vascularized biomaterials have been developed through various strategies. Stem cells are non-specialized cells that could either proliferate to expand the stem cell population or differentiate into various other cell types during their development. In this study, these factors have been investigated.

کلیدواژه ها:

smart biomaterial ، encapsulation ، injectable