One-Pot Synthesis Of 1,4-Benzodiazepine Derivatives Using Hetropoly acid Ionic Liquids Supported On Magnetic Nanoparticles Of CoFe2O4

Benzodiazepine derivatives are a highly valuable class of heterocyclic compound that possess various medicinal, biological and pharmaceutical activities such as anticonvulsant, anti-anxiety, antitumor, antipyretic and anti-inflammatory [1].The heteropoly anions are heterogeneous acid catalysts that used for dehydration reactions from diols, rearrangement, friedel-craftts alkylation and the synthesis of antioxidants, vitamins and biologically active substances. Research has shown that immobilization of heteropolyacids (HPAs) on a suitable support can eliminate its encountered major drawbacks, including very low surface area and instability in polar solvents. However, immobilization of heteropoly acids have more than acidic sites available for their crude state, thus exhibiting more catalytic activity [2].Introducing HPAs supported on magnetic nanoparticles can provide a means for effective separation of the catalyst from the reaction mixture, and it can be easily separated from the reaction by applying a simple permanent magnet [3]. We now wish to report, easy and efficient one pot synthesis of 1,4-benzodiazepine derivatives directly from dimedone, o-phenylenediamine and an aromatic aldehyde in high yields over short reaction times, easy work-up, reusability of the nanocatalyst using heteropolyacids ionic liquids supported on magnetic nanoparticles of CoFe2O4 under one-pot solventfree conditions.