Study of gene Polymorphisms correlated with allergic rhiniris disease in the northwest of Iran

An allergen is an otherwise harmless substance that causes an allergic reaction, especially in the spring and summer.Allergic rhinitis is one of a variety of allergic diseases that affects the upper respiratory tract, The prevalence of AR has been estimated to be between 15% and 20% and it is associated with numerous short-and long-term complications that impact the patient’s overall life quality, that contributes to the development of other medical conditions or health issues, such as asthma, sinusitis, anosmia, otitis media, nasal polyps, lower airway infection. There is clear evidence to support the concept that allergic rhinitisinfluenced by genetic predispositionand environmental exposure. The purpose of this study was to identify the key polymorphism of genes for AR. In this study, two groups, allergic rhinitis patients diagnosed by an allergy specialist as the case group and non-allergic rhinitis patients were selected as the control. DNA was extracted from peripheral blood of groups were evaluated for the genetic polymorphism aspect by PCR-RFLP and the results were analyzed with SPSS software.It has been shown that polymorphisms of candidate genes have been associated with clinical expression of these diseases in the northwest population of Iran. This study will help us to further develop new avenues for genetically oriented diagnosis and more effective measures of prevention and intervention. However, more epidemiological studies are needed to accurately identify genes affecting the Northwest population of Iran.

کلیدواژه ها:

Allergic rhinitis ، Polymorphism ، Northwest population of Iran