SESAME SEED AND ITS FRACTIONS FOR IMPROVING OXIDATIVE STRESS IN ADULTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CONTROLLED CLINICAL TRIALS

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 510

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شناسه ملی سند علمی:

INC15_354

تاریخ نمایه سازی: 30 دی 1397

چکیده مقاله:

Background and Aim: It is proposed that sesame products affect oxidative stress, although the findings were inconsistent. This study aimed to summarize the effect of sesame seed and its fractions on oxidative stress parameters in human adults using systematic review and meta-analysis. Methods: PubMed, Scopus, ISI Web of Science and Google Scholar were searched up to April 2018 to identify relevant controlled clinical trials. Random effects model was used for calculating the overall effects.Results: Fifteen clinical trials were eligible. Meta-analyses revealed that sesame consumption significantly increases enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (vitamin C, vitamin E, β-caroten and glutathione) antioxidants (P<0.05). It was shown that malondialdehyde levels significantly decreases only when sesame seeds were used for supplementation. However, no significant effect was observed on malondialdehyde (MDA) (Hedges g=-0.80, 95% confidence interval (CI): -1.69, 0.09; P=0.078), total antioxidant capacity (WMD=0.16, 95% CI: -0.19, 0.51; P=0.365) and α-tocopherol (WMD=-0.33, 95% CI: -1.11, 0.45; P=0.409) levels. It was shown that MDA levels significantly decreases only when sesame seeds were used for supplementation (Hedges g = -0.82, 95% CI: -1.24, -0.40, P<0.001).Conclusion: Sesame consumption is associated with improved oxidative status. High quality randomized controlled clinical trials from diverse regions are still needed.

نویسندگان

Fatemeh Moghtaderi

Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd,Iran

Nahid Ramezani-Jolfaie

Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd,Iran

Hamidreza Raeisi-Dehkordi

Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd,Iran

Amin Salehi Abargouei

Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd,Iran