BENEFICIAL HEALTH EFFECTS OF MENAQUINONE-7 ON BODY COMPOSITION, GLYCEMIC INDICES, LIPIDS PROFILES AND ENDOCRINE MARKERS IN PCOS PATIENTS

Background and Aim: Insulin resistance, the main cause of polycystic ovary syndrome (PCOS), targets secondary abnormalities such as cardiovascular disease and diabetes. Recent studies have suggested insulin sensitizers for the management of PCOS. The insulin-sensitizing effect of vitamin K has been demonstrated in previous studies. The aim of this study was to evaluate the effect of oral vitamin K2 (Menaquinone-7, MK-7) on clinical and biochemical parameters in PCOS patients.Methods: In this randomized double-blind, placebo-controlled clinical trial, 84 PCOS patients were randomly assigned into treatment (90µg MK-7 daily for 8 weeks) and placebo groups. Insulin resistance, lipid profile, endocrine biomarkers and body compositin of participants were measured before and after the intervention. Results: The consumption of MK-7 in compare to the placebo was associated with significant reductions in serum fasting insulin (P=0.002), homeostasis model of assessment insulin resistance (HOMA-IR, P=0.002) and homeostasis model of assessment β-cell function (HOMA-ß, P=0.02) besides a significant increase in quantitative insulin sensitivity check index (QUICKI, P=0.001).MK-7 administration also led to significant decrements of serum triglyceride (P=0.003), waist circumference (P=0.003) body fat mass (P<0.001), Dihydrotestosterone (DHT) (P=0.03) and free androgen index (FAI, P<0.001) as well as significant increments of skeletal muscle (P<0.001) and sex hormone binding globulin (SHBG,P<0.001).Conclusion: This study displays beneficial effects of MK-7 on improving insulin resistance/sensitivity, fat mass decrement, increasing skeletal muscles, and effective and significant alterations in TG, DHT and SHBG serum levels. So, it seems that it may be an appropriate alternative/additive treatment in PCOS patients.

کلیدواژه ها:

menaquinone-7 ، PCOS ، insulin resistance ، body composition ، endocrine system