Delivery of Methotrexate from Nano gel- Calcium Alginate beads

The objective of this study was to develop a sustained release dosage form Methotrexate (MTX) using a natural polymeric carrier prepared in a completely aqueous environment. MTX was entrapped in calcium alginate beads prepared with sodium alginate by the ionotropic nanogel method using calcium chloride as a crosslinking agent. The drug was incorporated either into preformed calcium alginate gel beads . Fourier transform infrared (FTIR), Thermal analysis (TG/DTA), scanning electron microscope (SEM) studies on this sysytem are discussed. The controlled release of MTX from Calcium alginate beads in buffer solution has been performed and monitored by UV–visible spectroscopy