Preparation and Characterization of Protein Nanoparticles from Human Serum Albumin (HSA) as a Novel Drug Delivery System
محل انتشار: ششمین کنگره بین المللی مهندسی شیمی
سال انتشار: 1388
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 2,394
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شناسه ملی سند علمی:
ICHEC06_435
تاریخ نمایه سازی: 1 مهر 1388
چکیده مقاله:
The aim of present study was to prepare human serum albumin (HSA) nanoparticle for drug delivery. These nanoparticles were prepared by desolvation method. The body distribution of colloidal drug delivery systems was mainly influenced by two physicochemical properties namely particle size and surface characteristics. The influence of several factors on the fabrication process including the pH value, HSA concentration [mg/ml], glutaraldehyde concentration [%], agitation speed [rpm] and the ratio of organic solvent/HSA solution were investigated herein. The smallest size of nanoparticles was 69 nm and the largest size was 424 nm which is suitable for drug delivery. The crosslinker concentration [%] and agitation speed [rpm] showed that have less effect on produced nanoparticle size. For characterizing the nanoparticle sample, atomic force microscopy (AFM) and scanning electron microscopy (SEM) was employed whilst size distribution was measured by photon correlation spectroscopy (PCS). It was shown that the produced nanoparticles were almost formed by a smooth surface. Based on these characteristics, HSA nanoparticles were good enough to be candidate for drug delivery. The mechanistic of the optimum conditions for preparing proteinnanoparticle as well as their characterization are discussed.
کلیدواژه ها:
نویسندگان
Rabeah Mehravar
۱Faculty of chemical engineering, Ferdowsi University of Mashhad, Mashhad, Iran
Mohsen Jahanshahi
Nanobiotechnology Research Group, Babol University of Technology, Babol, Iran
Naser Saghatoleslami
Faculty of chemical engineering, Ferdowsi University of Mashhad, Mashhad, Iran
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