The Effect of Pentoxiphyllin on Spermatogenesis Indexes and Daily Sperm Production in Mice Following Treatment with Dexamethasone
محل انتشار: چهارمین کنگره بین المللی تولیدمثل
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 451
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شناسه ملی سند علمی:
ISERB04_192
تاریخ نمایه سازی: 16 تیر 1397
چکیده مقاله:
Background: Dexamethasone is a common medicine used for treatment of sever allergies in human and able to induce disturbance in male reproductive system by inducing oxidative stress. Pentoxiphyllin as a potent antioxidant is able to reduce oxidative stress. The aim of this study was to evaluate the preventing effect of pentoxiphyllin on undesirable morphological changes in mice testis tissue treated with dexamethasone. Material and Method: 24 Adult male NMRI mice (36±2 gr.) were divide randomly into 4 groups (n=6): control, Dexamethasone (7mg/kg/day), Dexamethasone + pentoxiphylin (200mg/kg/day) and pentoxiphylin. After 7 days of intraperitoneal injection, testes weighted and fixed for stereological evaluation of testis morphological changes, daily sperm production and spermatogenesis indexes. Data was statistically analyzed using one-way ANOVA and tukey’s test, and the means were consider significant different at P<0/05. Results: A significant reduction in the mean total volume of testis, volume of seminiferous tubules, mean number of spermatocytes, round and long spermatids and Leydig cells, spermatogenesis indexes, daily sperm production was found in the Dexamethasone group compared to the control group (P> 0/05). The mentioned parameters were compensated to the control level in the Dexamethasone + pentoxiphylin group. Conclusion: This study showed that simultaneous treatment of pentoxiphyllin and dexamethasone can prevent the adverse effects of dexamethasone on mice testicular histological changes, spermatogenesis indexes. Therefore its application in the therapeutic regimens including Dexamethasone is suggested
کلیدواژه ها:
نویسندگان
Nasrin Kheradmand
Departement of Bioligy,Faculty of science,Arak university
Malek Soleimani
Departement of Bioligy,Faculty of science,Arak university
Monireh Mahmoodi
Departement of Bioligy,Faculty of science,Arak university