Preparation and characterization of drug-loaded poly(methyl methacrylate) nanoparticles by a microemulsion method

This work was aimed to synthesis and characterization of drug-loaded poly(methyl methacrylate) (PMMA) nanoparticles by use of a simple microemulsion method. The PMMA nanoparticles were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS) and Transmission Electron Microscopy (TEM) analysis. The zeta potential of the QU-loaded PMMA latex also was measured by the Zetasizer. The particles had the size of below 10 nm and were spherical with narrow size distribution with PDI value of 0.36. The zeta potential was obtaine about -20 mV that was confirmed good stability of the system. Consequently, this route was very useful for pharmaceutical carriers in drug delivery aims.

کلیدواژه ها:

Poly(methyl methacrylate) ، Nanoparticle ، Microemulsion