Molecular Modelling of Gelatin Bundles for Atomistic Investigations Suggesting Two Stable Conformations

سال انتشار: 1403
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 82

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شناسه ملی سند علمی:

NANOCDSTS03_064

تاریخ نمایه سازی: 10 آبان 1403

چکیده مقاله:

In nanobiotechnology, gelatin gels have broad application prospects because of their unique biocompatibility. In this study, we performed molecular docking analysis to predict the likely stable structural assemblies among gelatin strands. Using three docked synthetic gelatin strands, the conformations of these bundles were compared and all showed two conserved modes: triangular and straight-linear. The top-ranked clusters showed stable bundles, with triangular structures appearing in groups of three and five gelatin strands while linear bundles formed with four-strand arrangements. The findings offer information on how gelatin behaves structurally and its relevance in creating biomaterial products for nanobiotechnology applications, like drug delivery systems and tissue engineering projects.

نویسندگان

Seyed Mohammad Hasan Haghayeghi

Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran

Mohammad Assadizadeh

Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran

Ali Yousefzadeh Dastjerd

Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran