The effect of hydro alcoholic extract of Rorippa Nasturtium Aquaticum on morphology of sperm in prostate cancer induced by DMBA

Background: The prostate glands are the largest attached glands of the male reproductive system which play a key role in sperm fertility. Therefore, the aim of this study was to investigate the effect of hydro alcoholic extract of Rorippa Nasturtium Aquaticum on morphology of sperm in Prostate cancer induced by DMBA.Methods: In this research, forty-two male adult rats were divided to 6 groups: Normal, DMBA+ Normal saline, DMBA+ finasteride (Positive control),DMBA+ dose of 25 mg/kg (negative control), DMBA+ dose 75 mg/kg and DMBA+ dose 100 mg/kg of plant extract, respectively. Due to induction of anesthesia and surgery, direct injection of DMBA was performed into the prostate glands in rats. After ten days of the injection, the rats were gavaged for one Month. Finally, testis of rats were removed for sperm analysis.Result: In this study, morphology of sperm showed significant changes. So that, amount of abnormal morphology showed significant decreasing compared with normal and positive control groups with increasing dose.Conclusion: The results revealed that taking this plant extract can improve sperm morphology. Therefore, its prescription as a treatment supplement is recommended.

کلیدواژه ها:

DMBA cancer induction ، Morphology of sperm ، Rats ، Rorippa Nasturtium Aquaticum