Annexin A1, A2 and cytokine levels during experimental sepsis in calves
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 427
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شناسه ملی سند علمی:
JR_IJVST-9-1_002
تاریخ نمایه سازی: 1 اردیبهشت 1397
چکیده مقاله:
Annexins are fundamentally related proteins that process a variety of physiologic and pathologic procedures, including suppression of inflammation. Ten Holstein-Frisian bull calves (10 ± 1 days old) weighting 50 ± 5 kg were chosen to induce the experimental septicaemia using O111:H8 strain of E. coli. Blood samples were collected to determine the plasma annexin A1 , annexin A2, TNF-α, IFN- γ, IL-8 and neutrophil count at 0, 24, 48, 72, 96 and 120 hours after induction of septicemia. Significant increased concentrations of serum annexin A1 and annexin A2 in circulating blood in response to experimental coliseptisemia were observed during experiment. Maximum levels of annexinA1 and A2 were recorded at 72h after challenge. A statistically significant increase in blood neutrophil count occurred from beginning of septicemia untill 24h after onset of septicemia. Annexin A2 and Annexin A1 had no significant correlation with neutrophil count. Serum cytokine concentrations reached their maximum level at 48h after challenge and then decreased to basal level before antibiotic therapy. This study showed that serum annexin concentrations, increasing during colisepticemia in calves, in association with cytokines could be a reliable marker to confirm the occurrence of anti-inflammatory response.
نویسندگان
Mohammad Reza Mokhber Dezfouli
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Zohre Eftekhari
Research & Production Complex, Pasteur Institute of Iran, Tehran, Iran
Masoomeh Heidari Sureshjani
Department of Dignostic Microbiology, Central Veterinary Laboratory of Iran Veterinary Organization, Tehran, Iran
Mohammad Mahdi Dehghan
Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran