A Review of the Size and Zeta Potential of Nano-Carriers PLGA-Cs with the Aim of Increasing the Effectiveness of Paclitaxel Anti-Cancer Drug

Cancer is a major cause of death with more than 10 million annual patients. It is possible that this numberreaches 15 million patients per year by 2020. Though chemotherapy has largely been successful in controllingand treating cancer, live tissue damage, systemic toxicity and side effects in this method are among the issuesthat cannot be overlooked. In order to reduce the negative effects of anticancer drugs on normal tissues, we needto design Nano-sized carriers that can pass the safety barriers and body tissues and reach their target site. Inthis paper, the size and zeta potential of Nano-carriers PLGA-Cs-Paclitaxel were evaluated. Chitosan connectionin physical or conjugated forms may lead to a significant increase of polydispersity. According to the studycarried out on the concentration of Chitosan and the type of absorption, it was concluded that nanoparticles sizeincreases with higher concentrations of Chitosan. The zeta potential will increase, provided the conjugation ofChitosan is higher than physical adsorption.

کلیدواژه ها:

Anticancer drugs ، Nano-carriers PLGA-Cs ، Particles Size ، Zeta Potential