A Simple Chemiluminescence Method for Direct Determination of Biperiden in Pharmaceuticals
محل انتشار: اولین کنفرانس بین المللی فناوری های نوین در علوم
سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 422
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شناسه ملی سند علمی:
CMTS01_150
تاریخ نمایه سازی: 17 آبان 1396
چکیده مقاله:
A sensitive and simple chemiluminescence (CL) method has been developed for direct quantification assay of biperiden, a medication used to treat Parkinson disease, in pharmaceutical dosage forms. In the proposed method acidic potassium permanganate was used as a CL reagent. In this method, the CL intensities were linear over the concentration ranges 4.0-15.5 µg mL-1 and 15.5-65.5 µg mL-1 and the speed of analysis was calculated approximately 40 samples h−1. The LOD was 12.4 ng mL-1 (signal to noise =3) and the percent of relative standard deviation (in 6 replicate measurements) was 5.6% for 4.1 µg mL-1 biperiden. The method successfully applied for the determination of biperiden in pharmaceuticals.
کلیدواژه ها:
نویسندگان
Jalal Niazi Saei
Department of Chemistry, Golestan University, Gorgan, Iran
Ali Mokhtari
Department of Chemistry, Golestan University, Gorgan, Iran
M. Mottaghi Nasab
Department of Chemistry, Golestan University, Gorgan, Iran
a Makhtoomi
Department of Chemistry, Golestan University, Gorgan, Iran