A Simple Chemiluminescence Method for Direct Determination of Biperiden in Pharmaceuticals

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 422

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شناسه ملی سند علمی:

CMTS01_150

تاریخ نمایه سازی: 17 آبان 1396

چکیده مقاله:

A sensitive and simple chemiluminescence (CL) method has been developed for direct quantification assay of biperiden, a medication used to treat Parkinson disease, in pharmaceutical dosage forms. In the proposed method acidic potassium permanganate was used as a CL reagent. In this method, the CL intensities were linear over the concentration ranges 4.0-15.5 µg mL-1 and 15.5-65.5 µg mL-1 and the speed of analysis was calculated approximately 40 samples h−1. The LOD was 12.4 ng mL-1 (signal to noise =3) and the percent of relative standard deviation (in 6 replicate measurements) was 5.6% for 4.1 µg mL-1 biperiden. The method successfully applied for the determination of biperiden in pharmaceuticals.

نویسندگان

Jalal Niazi Saei

Department of Chemistry, Golestan University, Gorgan, Iran

Ali Mokhtari

Department of Chemistry, Golestan University, Gorgan, Iran

M. Mottaghi Nasab

Department of Chemistry, Golestan University, Gorgan, Iran

a Makhtoomi

Department of Chemistry, Golestan University, Gorgan, Iran