Cuckoo Search Algorithm and Its Application For Secondary Protein Structure Prediction

Protein structure prediction (PSP) is one of the most challenging problems in the field of structural bioinformatics. Determining native conformation of a protein canaffect its functions and plays an important role in drug design and disease prediction. Therefore, researchers are trying to comeup with different techniques in order to find more precise structures. This study investigates the application of Cuckoo Search (CS) algorithm on the protein folding problem based onAB off-lattice model. The experiments are conducted on a set of protein sequences that are suggested in the literature. For thepurpose of evaluation, we used state-of-the-art and previously published algorithms. Comparison of the statistical results demonstrates that CS outperforms other algorithms in a meaningful way.

کلیدواژه ها:

Protein structure predication ، AB off-lattice model ، optimization ، cuckoo search