Coumarin derivatives binding to ATP-binding cassette trasporter ABCC1 ; A Virtual screening

Drug resistance is the fundamental obstacle in chemotherapy of cancer patients [1]. ABCC1belonging to ATP-binding Cassette (ABC) transporters plays important role because of theiractively deport anti-cancer drugs from cells [2]. Here we have studied molecular modeling ofcoumarin, a plant-derived benzopyrone with many pharmacological benefices [3] and itsderivatives as ABCC1 inhibitor.