Amperometric sensing of anti-HIV drug, Nevirapine, on nanocomposite modified glassy carbon electrode

This work describes the synthesis of silver nanoparticles functionalized with 11- mercaptoundecanoic acid and thiosemicarbazide that covalently attached to the multi wall carbonnanotube (MWCNT) on the surface of glassy carbon electrode. The modified glassy carbon electrode was used to electrochemical oxidation study and determination of antiretroviral drug Nevirapine (NEV). NEV is the first member of the non-nucleoside reverse transcriptaseinhibitors that licensed for the treatment of AIDS [1]. Various techniques have been developed for the analysis of NEV. In spite of the great success of these methods, their high costs, timeconsumingand complicated operations, limit their applications in routine laboratories. Only afew electrochemical methods has been presented for determination of NEV [2,3]. Hence, the aim of this work was to construct of a novel electrochemical sensor for determining the concentration of NEV in human serum samples and dosage forms. The proposed sensor’s respond showed good accuracy and reproducibility to NEV and exhibited excellent characteristics by amperometry such as a wide linear range from 4 to 80 μM, a low detectionlimit of 200 nM, high sensitivity. These results showed the efficient catalytic property of the AgNPs-TSC/MWCNTs nanocomposite modified glassy carbon electrode toward NEV determination.

کلیدواژه ها:

Nevirapine ، anti-HIV drug ، Ag nanoparticles ، MWCNTs ، modified glassy carbon