Electrocatalytic determination of captopril using a ferrocene-derivative modified nanostructure carbon paste electrode

Hypertension (high blood pressure) is a risk factor and increases human chance of developing heart disease. For treatment of hypertension we can lose weight if it is overweight, cutting backif we drink a lot of alcohol, regular physical activity, stopping smoking, and using medication treatment with usual drugs such as captopril [1]. CAP is used to treat hypertension, congestive heart failure, diabetes kidney problems, and to improve survival after a heart attack. However,CAP is not recommended for pregnant women [2]. According to the above points, suggestion of a high sensitive and selective volammetric sensor is very important for CAP determination in drug and urine samples. The study of electrochemical behavior and determination of captopril, as an angiotensinconvertingenzyme inhibitor using a 1, l′-bis(2-phenylethan-1-ol)ferrocene modified ZnOnanoparticles carbon nanotubes paste electrode is reported. The cyclic voltammetric results indicate that the modified electrode system can remarkably enhance electrocatalytic activitytoward the oxidation of captopril in aqueous buffer solution pH 8.0. Under the best experimental conditions selected, the calibration curve for captopril was linear in the concentration range from 0.09 to 450 μM and a detection limit of 0.05 μM was obtained. The influence of pH andpotential interfering substances on the determination of captopril were studied. Electrochemical impedance spectroscopy was used to study the charge transfer properties at the electrode– solution interface. Finally, the sensor was examined as a selective, simple, and precise newelectrochemical sensor for the determination of captopril in real samples, such as drugs and urine. Satisfactory results were obtained.

کلیدواژه ها:

Captopril analysis ، ZnO nanoparticles ، Ferrocene derivative ، Voltammetric analysis