Electrochemical Investigation of Releasing of dopamine from dopamineloaded liposomes

The formulation of liposomes has remarkable effect on encapsulation property of them. In this study, dopamine-loaded liposomes were prepared through thin layer hydration method. The releasing behavior of loaded dopamine was investigated through immobilizing of biotin tagged liposomes on streptavidin coated micro plates. Two formulations were investigated with different molar ratios of lecithin: cholesterol. For 10:1 molar ratio of lecithin:cholesterola higher loadingof dopamine and rapid releasing of dopamine was observed, in contrast for 1:1 molar ratio lower loading and higher stability was obtained.

کلیدواژه ها:

Dopamine-loaded liposomes ، electrochemical study ، Formulation ، Biotin tagged liposomes