Effect of body weight on serum homocysteine level in patients with polycystic ovarian syndrome: A case control study
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 393
فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJRM-14-2_002
تاریخ نمایه سازی: 16 شهریور 1395
چکیده مقاله:
Background: Polycystic ovarian syndrome (PCOS) represent one of the common endocrine disorders which influence around 8% of reproductive women whomusually suffering from obesity and increase cardiovascular risk. Serum homocysteine levels are associated with bad impact on endothelial functions andconsidered as an independent risk factor for cardiovascular disease. Objective: The aim was to study the level of plasma homocysteine in obese and non-obese Iraqi patients with PCOS. Materials and Methods: This study was carried out on 207 women. Of theme, 101 women with PCOS and 106 PCOS- free women served as controls. Blood sample was taken from each participant on the 2PndP day of menstruation morning after an overnight fasting. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), free testosterone and androstenedione were measured. Moreover, total lipid profile and plasma homocysteine levels were measured in both groups.Results: Sixty percent of PCOS women were overweight or obese and 56% of them had a waist circumference >88cm. Moreover plasma homocysteine concentrations were found to be higher in patients with PCOS (11.5±5.41μmol/L) as compared with control (8.10±1.89 μmol/L) (p<0.002). Furthermore the homocysteine concentrations were 13.19±5.97 μmol/L and 9.38±2.99 μmol/L in both obese and normal-weight PCOS women respectively which was significantly higher than obese (p<0.002) and normal-weight (p<0.004) control women.Conclusion: Increase in body weight is not an independent risk factor to increase plasma homocysteine levels in PCOS women.
کلیدواژه ها:
نویسندگان
Ali I. Al- Gareeb
Department of Clinical Pharmacology and Therapeutics, College of Medicine, Al- Mustansiriya University, Baghdad, Iraq
Wafaa Salah Abd Al- Amieer
Department of Obstetrics and Gynecology, Al-Kadhymia Teaching Hospital, Baghdad, Iraq.
Hayder M. Alkuraishy
Department of Clinical Pharmacology and Therapeutics, College of Medicine, Al- Mustansiriya University, Baghdad, Iraq
Thabat J. Al- Mayahi
Department of Obstetrics and Gynecology, Al- Kadhymia Teaching Hospital, Baghdad, Iraq.