Effect of Cnidoscolous aconitifolius (Miller) I.M.Johnston leaf extract on reproductive hormones of female rats
محل انتشار: مجله طب تولید مثل ایران، دوره: 6، شماره: 1
سال انتشار: 1387
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 339
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شناسه ملی سند علمی:
JR_IJRM-6-1_008
تاریخ نمایه سازی: 16 شهریور 1395
چکیده مقاله:
Background: The increase in the rate of infertility in women has prompted the need to search for plants with antifertility potentials. Objective: The effect of administration of aqueous extract of Cnidoscolousaconitifolius leaves for seven days on reproductive hormones of female Wistar rats was investigated. Materials and Methods: Sixty female albino rats were grouped into four (A, B, C and D) of 15 each. Group A (the control) received orally 6.5 ml kg-1 body weight of distilledwater on daily basis for 7 days. Groups B, C and D were treated like the control except that they received 250, 500 and 1000 mg kg-1 body weight of the extract.Results: Phytochemical screening of the extract revealed the presence of alkaloids,saponins, phenolics, tannins, flavonoids, anthraquinones, phlobatannins and triterpenes. Administration of the extract produced significant increase (p<0.05) in the serum prolactin concentration whereas those of estradiol, progesterone, follicle stimulating and luteinizing hormones were significantly reduced. Conclusion: The alterations in the female rat reproductive hormones by the extract are indications of adverse effect on the maturation and ovulation of follicles. Consequently,the extract may impair fertility and conception in female rats. Thus, the Cnidoscolous aconitifolius leaf extract may be explored as a female contraceptive.
کلیدواژه ها:
نویسندگان
Musa Toyin Yakubu
Department of Biochemistry, Faculty of Sciences, University of Ilorin, Ilorin, Nigeria.
Musbau Adewumi Akanji
Department of Biochemistry, Faculty of Sciences, University of Ilorin, Ilorin, Nigeria.
Adenike Temidayo Oladiji
Department of Biochemistry, Faculty of Sciences, University of Ilorin, Ilorin, Nigeria.
AbdulWaheed Olajide Olatinwo
Department of Obstetrics and Gynecology, Faculty of Clinical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.