Anti colon cancer efficacy of Ferula assa-foetida in modulating the detoxification enzymes and β-catenin

The present study was undertaken to investigate the chemotherapeutic activity of Ferula (F.) assa-foetida hydroalcoholic extract on colon cancer induced by 1,2 dimethylhydrazine (DMH) in rat. Rats were classified into 4 groups: a control group without DMH; a group with injected DMH and two groups receiving F. assa-foedita extracts after DMH injection as chemotherapeutic groups. The effects of the extracts were tested by estimating the detoxification enzymes (GST & CYP 450). In following, the colon tissues were collected for colonic β-catenin assessment and histopathological analysis. The results showed that the treatment of cancer group with F. assa-foedita indicated a significant decrease in the expression levels of β-catenin and CYP450 together with the elevation of GSTs (activity and protein). These data are in parallel with decreased ACF formations in histopathological biopsies in F. assa-foedita extract treated groups. Thus, the results obtained from the present study suggested the F. assa-foedita extracts as an effective chemotherapeutic agent on colon carcinogenesis induced by DMH.

کلیدواژه ها:

DMH ، Ferula assa-foetida ، β - catenin ، DMH ، Chemotherapy ، Colon carcinogenesis