Monoclonal antibodies as tumor targeting agents in multiplemyeloma

سال انتشار: 1394
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 521

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شناسه ملی سند علمی:

NEWCONF02_086

تاریخ نمایه سازی: 12 تیر 1395

چکیده مقاله:

Multiple myeloma (MM) is a hematological malignancy that remains incurable becausemost patients will eventually relapse or become refractory to the treatments. Novel agentsare currently in development for the treatment of relapsed/refractory MM, includingimmunomodulatory drugs, proteasome inhibitors, monoclonal antibodies, cell signalingtargeted therapies, and strategies targeting the tumor microenvironment. for this purposethe conformational structure of the hexapeptide H3N+-FDDARL-COO-, H3N+-FVDVRLCOO-, H3N+-FSDARL-COO- has been investigated by the PCILO method. Thecomputational results show this tree structure have no functionality group for bind to Mprotein. Moreover, H3N+-FVDVRL-COO- has assumes the somewhat amphipathicstructure

نویسندگان

Fereshteh Ezzatighadi

Department of Plant Biology, Faculty of Sciences, University of Jiroft, Jiroft,Kerman, Iran

Abdollah Ramzani Ghara

Department of Plant Biology, Faculty of Sciences, University of Jiroft, Jiroft,Kerman, Iran