Effects of Particle Size Distribution on In-vitro Release Behavior of Chitosan Nanoparticles Containing Salicylic acid as an Oral Drug Delivery System

Nanoparticulate drug delivery systems have the potential to improve drug stability, increase the duration of the therapeutic effect and permit administration through non-parental routes. Oral delivery is the preferred route for administration because it is non-invasive, avoids injection, and decreases risk of infection [1]. Chitosan is regarded as a biocompatible, biodegradable, natural origin polymer and widely used in the food industry. Chitosan has proven to be a potent adsorption enhancer of peptide drugs by opening the tight junctions between epithelial cells, thereby facilating the paracellular transport of hydrophilic compounds [2,3]. Salicylic acid (SA) is a betahydroxy acid (BHA) with the formula C6H4 (OH) CO2H, which is used to treat warts, corns, acne, psoriasis, etc [4]. The short half life, low bioavailability and sever gastric irritation, make SA a very good candidate for present study. In present study, SA-nanoparticles were prepared by emulsion technique. The effects of physical condition on two different particles size distribution and the effects of particle sizes on drug content and release properties were investigated.