Smart Glucose-Responsive Hydrogel Drug Delivery Systems for Bone Regeneration in Diabetic Patients: A Comprehensive Review

Smart biomaterials have recently gained significance in biomaterial research. Glucose-responsive hydrogels are prime examples of smart biomaterials for bone regeneration. These hydrogels utilize glucose concentration gradients enable the controlled release of therapeutics, surpassing traditional methods. Laboratory studies on these hydrogels have shown promising results; however, challenges such as enzymatic stability and reproducibility in production hinder their clinical translation and commercialization. This study examines the significance of smart biomaterials and hydrogels for drug delivery, focusing on production challenges such as fabrication techniques, enzyme immobilization, and AI integration in hydrogel design.

کلیدواژه ها:

Glucose-responsive hydrogels ، Smart biomaterials ، Bone regeneration ، Drug Delivery