Synthesis of pH-sensitive smart nanohydrogel based on hyaluronic acid/gelatin/cyclodextrin for drug delivery applications

In this study, smart nanohydrogels based on hyaluronic acid, gelatin, and cyclodextrin were synthesized by the emulsion method. The goal was to design a pharmaceutical system capable of responding to environmental changes. The chemical structure and the presence of bonds between components were confirmed using FTIR spectroscopy. The particle size distribution and stability of nanohydrogels were investigated using the DLS technique, indicating their high sensitivity to pH changes. The findings show that these nanohydrogels have potential for controlled drug release and targeted medicinal applications.

کلیدواژه ها:

Cyclodexterin ، Gelatin ، Hyaluronic acid ، smart nanohydrogel