Synthesis of pH-sensitive smart nanohydrogel based on hyaluronic acid/keratin/cyclodextrin for drug delivery applications

In this study, pH-sensitive nanohydrogels composed of hyaluronic acid, keratin, and cyclodextrin were developed to enhance the efficiency of pharmaceutical systems. The nanohydrogel chemical structure was confirmed using FTIR spectroscopy. Furthermore, the DLS test determined the particles size and their distribution, demonstrating the nanoparticles' uniformity and stability. The pH response behavior assessment revealed significant changes in particle size and swelling at different pH environments, making the designed nanohydrogel a promising option for controlled and targeted drug release.

کلیدواژه ها:

Cyclodextrin ، Drug delivery ، Hyaluronic acid ، pH-responsive nanohydrogel