Background: Iran is rich in a diverse range of medicinal plants with significant potential for managing blood pressure. This review examines various plants, including black cumin, crataegus, garlic, lemon balm, and rose hips, which exhibit potential antihypertensive properties supported by scientific literature. The present study aimed to investigate the effect of secondary metabolites from Iranian medicinal plants on the treatment of various diseases, particularly hypertension and heart attacks, by examining their impacts on transcription factors and signaling pathways. Methods: We reviewed ۱۰۰ articles from clinical studies, of which ۴۹ specifically addressed the impact of medicinal plants on blood pressure regulation. The primary database utilized was Google Scholar, focusing on articles with an impact factor exceeding ۲. Selection criteria were established based on the relevance of secondary metabolites to blood pressure control. Results: Medicinal compounds of plants, known as secondary metabolites, suppress cancer metastasis and inhibit a wide range of diseases, including blood pressure and heart attacks, through their effects on transcription factors and signaling pathways. Conclusion: Clinical studies show that active compounds in plants, particularly black cumin, cause vasodilation and reduce blood pressure. In contrast to conventional antihypertensive medications, which are associated with significant side effects such as drug dependence and resistance, medicinal plants offer a promising alternative for alleviating disease symptoms through their effects on transcription factors.

کلیدواژه ها:

Blood pressure ، Medicinal plants ، Secondary metabolites ، Heart disease ، Transcription factors ، Suppression of cancer metastasis