The Association between Adherence to the MIND Diet and Depression and Anxiety in Irritable Bowel Syndrome Patients

Irritable Bowel Syndrome (IBS) is one of the most common functional gastrointestinal disorders. Accordingly, this study aims to investigate the association between adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and the odds of anxiety and depression among patients with IBS. Methods: This multicenter cross-sectional study was conducted from ۲۰۲۱ to ۲۰۲۳ in three university-affiliated centers in Iran. A total of ۲۶۲ IBS patients aged ۱۸–۶۰ (۱۶۸ males, ۹۴ females; mean age ۲۹.۷۲ ± ۱۰.۱۹ years) were recruited based on the Rome III criteria. Dietary intake was assessed using a validated ۱۶۸-item food frequency questionnaire, and MIND diet scores were calculated. Anxiety was measured using the Hospital Anxiety and Depression Scale (HADS), and depression was assessed using the Patient Health Questionnaire-۹ (PHQ-۹). Logistic regression analyses were performed to estimate the odds ratios (ORs) for anxiety and depression across MIND diet score tertiles, adjusting for potential confounders. Results: Higher adherence to the MIND diet was significantly associated with lower odds of both anxiety (OR: ۰.۶۹, ۹۵% CI: ۰.۵۳–۰.۸۹, P=۰.۰۰۵) and depression (OR: ۰.۷۳, ۹۵% CI: ۰.۵۹–۰.۹۱, P=۰.۰۰۶) in IBS patients. Additionally, an inverse relationship was observed between MIND diet adherence and the severity of IBS symptoms (OR: ۰.۷۰, ۹۵% CI: ۰.۵۲–۰.۹۴, P=۰.۰۲). Conclusion: Greater adherence to the MIND diet was associated with reduced odds of anxiety and depression, as well as lower severity of IBS symptoms. Further prospective and interventional studies are warranted to confirm these findings

کلیدواژه ها:

Irritable Bowel Syndrome ، MIND diet ، Anxiety ، Depression ، Cross-sectional ، Psychological disorders.