Comparative Analysis of Serum Levels of Calcium, Phosphorus, Magnesium, and Zinc in Individuals with Metabolic Syndrome versus Healthy Control

Metabolic syndrome (MeTS) is directly associated with an increased risk of cardiovascular diseases and diabetes. The present study aimed to compare serum levels of calcium, phosphorus, magnesium, and zinc in the MeTS and control groups and determine the relationship between serum levels of calcium, phosphorus, magnesium, and zinc and components of MeTS. Methods: This case-control study was conducted on ۱۴۹ individuals (۷۹ people with MeTS and ۷۰ healthy individuals). Demographic data, including age, gender, body mass index (BMI), waist circumference, and blood pressure, as well as laboratory data, including fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein (HDL-C), magnesium, calcium, phosphorus, and zinc, were collected. Results: The results indicated that serum zinc levels were significantly lower in MeTS group, while serum phosphorus, calcium, and magnesium levels did not show significant differences between the two groups. Furthermore, serum zinc levels significantly decreased as MeTS factors increased, particularly with ۴ or ۵ factors. Serum zinc levels were significantly associated with blood pressure, BMI, and HDL-C. Similarly, serum magnesium levels showed a significant association with total cholesterol. Serum calcium levels were linked to both HDL-C and BMI. In contrast, serum phosphorus levels showed no significant association with any components of MeTS. Conclusion: Decreased serum zinc levels appear to be significantly related to MeTS and its components, including blood pressure and HDL-C. However, the relationship between serum calcium, phosphorus, magnesium, and zinc levels and MeTS requires further studies.

کلیدواژه ها:

Metabolic syndrome ، Zinc ، Calcium ، Phosphorus ، Magnesium ، Blood pressure ، Blood lipids.