Exploring the Influence of Gut Microbial ẞ-Glucuronidases on Cancer Progression and Treatment Strategies

Background and aim: The human gut harbors a complex community of microorganisms that play a crucial role in health and disease. Among these, microbial ẞ-glucuronidases have emerged as significant enzymes that can modulate the bioavailability and efficacy of various therapeutic agents, especially in the context of cancer progression and treatment. These enzymes can influence drug metabolism, the activation of prodrugs, and the detoxification of carcinogens, potentially impacting cancer development and therapeutic responses. The aim of this review is to explore the influence of gut microbial ẞ-glucuronidases on cancer pathways, their contributions to treatment outcomes, and the implications for future therapeutic strategies. Methods: This study is a review study by searching scientific databases such as Scopus, PubMed, and Embase from ۲۰۱۴ to ۲۰۲۴ by using the keywords Gut microbiome, ẞ-glucuronidases, cancer progression, treatment strategies, ۴۳ articles related to inclusion criteria were extracted and then analyzed. Results: The results indicate that gut microbial ẞ-glucuronidases can significantly alter the metabolism of several anti-cancer agents, potentially enhancing therapeutic efficacy and reducing adverse effects. Elevated levels of ẞ-glucuronidases have been associated with a better response to certain chemotherapeutic drugs, suggesting a correlation between the gut microbiome and drug metabolism. However, challenges persist, including the need for personalized approaches to modify gut microbiota composition and enzyme activity to optimize therapeutic outcomes. Additionally, the bidirectional influence between microbial activity and host immune responses presents further complexities in understanding the full impact on cancer dynamics. Conclusion: The exploration of gut microbial ẞ-glucuronidases reveals their potential as critical modulators in cancer progression and treatment. A deeper understanding of these enzymes and their interactions with therapeutic agents could pave the way for innovative treatment strategies that leverage the gut microbiome to enhance cancer therapy. Future research is essential to clarify the mechanisms involved and to develop targeted interventions that can manipulate gut microbiota for improved cancer outcomes.

کلیدواژه ها:

Gut microbiome ، ẞ-glucuronidases ، cancer progression ، treatment strategies