Mannose-Binding Lectin Gene and Promoter Variants in Infection-Related Kidney Dysfunction

The aim of present study is to determine the distribution of the alleles of mannose-binding lectin gene and promoter variants in infections that cause renal dysfunctions. Fifty eight renal recipients' samples which lost their kidneys in result of infection have compared with ۱۲۰ normal controls from Azarbaijan population of Iran. Blood samples were obtained from renal transplant recipients who received renal from March ۲۰۰۴ to July ۲۰۰۵. Mannose-binding lectin genotypes have investigated by polymerase chain reaction and restriction fragment length polymorphism. Allelic and genotypic frequency of the polymorphism at position -۵۵۰, +۴ and at codon ۵۲ and ۵۷ did not show statistical differences between infected patients and controls (p>۰.۰۵) but significant frequency of allele B (codon ۵۴) (p = ۰.۰۰۱۱) and Ly (p = ۰.۰۰۷), Lx haplotype (p = ۰.۰۰۰۲) of promoter was observed in this patients and allele A was more frequent in healthy patients. Present findings provide evidence that presence of different alleles and haplotypes that cause low concentration of mannose-binding lectin in serum is a risk factor for susceptibility to renal infections that cause renal dysfunction.

کلیدواژه ها:

Mannose-binding lectin ، Promoter ، Variant ، Infection