Burn Wound Healing Effect of Traditionally Used Persian Medicine Ointment Containing Herbal Extracts and Yogurt Butter

This study aimed to assess the burn healing efficacy of this traditionally used formulation (herbal ointment) in deep second-degree burns in a Florida white rabbit model. On the dorsal surface of the two rabbits, six burn wounds of the same size were inflicted. Herbal ointment was applied to the wounds on the right side, and silver sulfadiazine was applied to the wounds on the left side. On the ۵th and ۱۸th day of the treatment, the burn wound site was excised in a square shape with a narrow surrounding healthy skin for histopathological examination. At the end of day ۱۸ of the treatment period, all the ulcers in the traditional herbal ointment group were covered entirely with epithelial tissue, while in the silver sulfadiazine group, the mean and SD of the ulcer diameter were (۱.۴ ± ۰.۱). The duration of pain, blister, and open wound in the silver sulfadiazine group was ۶, ۸, and ۱۸ days; however, in the traditional herbal ointment group, on the second day, none of these complications were observed. Regarding the pathological findings, epithelial tissue renewal on day ۱۸th was ۶.۶۳ ± ۰.۷۴ in the traditional herbal ointment group compared to ۴.۹۳ ± ۰.۴۸ in the silver sulfadiazine (P< ۰.۰۵). The findings indicate that the traditional herbal ointment can reduce the duration of the wound healing process as well as the complications, including pain and blister formation. The pathological findings also suggest better epithelial tissue renewal in the traditional herbal ointment group.

کلیدواژه ها:

Burn wound ، Persian medicine ، Herbal ointment ، Yogurt butter ، Silver sulfadiazine