Comparative Molecular Docking Analysis of Curcumin and EGCG on CDK۱ Protein in Gastric Cancer

Gastric cancer remains one of the most prevalent and deadly forms of cancer globally. Cyclin-dependent kinase ۱ (CDK۱) plays a crucial role in cell cycle progression and has emerged as a potential target for anti-cancer therapies. In this study, we performed a molecular docking analysis using PyRx to compare the binding affinities of Curcumin and Epigallocatechin gallate (EGCG) to CDK۱. The results indicate that EGCG showed a binding affinity of -۷.۳ kcal/mol, while Curcumin showed -۶.۶ kcal/mol. These findings suggest that EGCG may exhibit a stronger interaction with CDK۱, supporting its potential as a therapeutic candidate in gastric cancer treatment.

کلیدواژه ها:

Gastric cancer ، CDK۱ ، Curcumin ، EGCG ، molecular docking ، PyRx ، binding affinity