Background and Purpose: The trace mineral selenium (Se) is one of the most critical micronutrients significantly affecting public health. It is a vital component in numerous enzymes and proteins, called selenoproteins; hence Se plays a crucial role in the range of biological activities.
Hashimoto's disease is the most common cause of hypothyroidism. In addition to
Selenium being a crucial micronutrient for thyroid health, there is a direct association between
Selenium and liver health. This study is aimed to examine the selenium effect on lipid factors, thyroid factors(anti-TPO and TSH), and liver enzymes. Method: A double-blinded, randomized clinical trial was conducted by enrolling ۴۰ patients with Hashimoto's thyroiditis in two equal control (placebo) and intervention (Selenium) groups. Two hundred micrograms of
Selenium were admitted to participants for ۶۰ days. Blood samples were obtained before and after the intervention. Total blood catalase, malondialdehyde, serum lipid profile, and liver factors were measured by spectrophotometric method, and the results were analyzed. Results: Plasma MDA level decreased significantly under the influence of selenium consumption, and hemoglobin levels in the experimental group showed a significant increase after the intervention (P <۰.۰۵). Catalase enzyme, lipid profile components, and liver enzymes in the intervention group did not change significantly compared to pre-intervention and the control group (P >۰.۰۵). TSH and anti-TPO levels indicated a relative decrease in the intervention group(P>۰.۰۵).Conclusion: According to our findings,
Selenium consumption in Hashimoto’s thyroiditis was associated with improved levels of serum lipid factors, liver enzymes, anti-thyroid peroxidase antibody, MDA, and HGB levels.
