An Innovative Approach: Soft Plasma-Modified Polycaprolactone-Alginate Nanofiber Bioactive Glass with Silver Nanoparticles and PRP for Bone Tissue Regeneration

This study aimed to assess the potential of Platelet-Rich Plasma (PRP) and extracted platelets from rabbits in promoting bone regeneration by utilizing Bioactive Glass (BG) and chitosan/gelatin membranes. The objectives were to accelerate the healing process, enhance biocompatibility, and provide anti-inflammatory properties. Silver nanoparticles ranging from ۸ to ۱۰ nm were incorporated into the scaffold to prevent microbial growth. The findings indicate that PRP injection into the lesion or in combination with synthetic BG can accelerate bone cell growth and regeneration while avoiding inflammation or infection. Moreover, the mechanical performance of the regenerated tissue was enhanced, and favorable biological properties were observed. The results demonstrate that PRP and BG can effectively treat bone lesions by promoting cell adhesion and early bone tissue regeneration. The data suggests that an increase in total porosity leads to a corresponding increase in overall porosity, with S۴ exhibiting the highest overall porosity of over ۷۰%. Furthermore, as total porosity increases, the percentage of apatite formation also increases, with S۴ displaying the highest formation percentage of over ۴۸%. Additionally, incorporating BG and chitosan/gelatin membranes, along with silver nanoparticles, enhances the material's biocompatibility. Further research is warranted to explore the clinical potential of this approach.

کلیدواژه ها:

Chitosan/gelatin ، Bioactive glass ، Silver nanoparticles ، PR ، Scaffold