Cardiac Troponin -T Release After Sport and Differences by Age, Sex, Training Type, Volume, and Intensity: A Critical Review

Background: Cardiac troponin T (cTnT) is a vital biomarker for assessing heart muscle damage, traditionally associated with myocardial infarction. Recent studies have shown that cTnT levels can increase after physical exercise, even in healthy individuals, suggesting that such increases may not always indicate pathological conditions. This review examines the release of cTnT post-exercise across various populations, considering age, gender, type of exercise, volume, and intensity to better understand the physiological implications of these findings. Methods: This review systematically analyzes the existing literature published between ۲۰۰۰-۲۰۲۳ regarding cTnT levels after exercise in children and adolescents aged ۶ to ۱۷.۹ years. A total of ۳۲۸ records were identified, with ۲۳ studies meeting the inclusion criteria after a thorough screening and quality assessment by independent reviewers. The analysis also focused on the demographics of participants, exercise methods, timing of sample collection, and the relationship between exercise intensity and cTnT levels. Results: The findings indicated that cTnT levels typically peaked ۳-۶ hours post-exercise and returned to baseline in most individuals within ۲۴ hours. This review highlighted a consistent relationship between exercise intensity/duration and increased cTnT. Specifically, less-trained individuals exhibited higher cTnT levels after aerobic activities compared to their more trained counterparts. The study also noted that factors such as age and gender did not significantly alter cTnT release patterns during exercise. However, variations were observed based on the type of training, with high-intensity workouts leading to more significant increases in cTnT levels than moderate or low-intensity exercises. Conclusion: This review emphasizes that while elevated cTnT levels after exercise are common in healthy individuals, they should be interpreted with caution in clinical settings. Understanding the physiological basis for these elevations is crucial for distinguishing between benign and pathological conditions. The findings suggest that clinicians should consider exercise history when evaluating troponin levels in patients presenting with chest pain or other cardiac symptoms.

کلیدواژه ها:

Cardiac troponin T ، exercise physiology ، biomarker release ، age differences ، training intensity