Nanoparticle-Based Delivery Systems For Taxol In Cancer Therapy: Enhancing Efficacy And Reducing Toxicity

The use of nanoparticles for the delivery of chemotherapeutic agents has emerged as a promising approach in cancer therapy due to their ability to improve drug solubility, enhance bioavailability, and achieve targeted delivery. Taxol (paclitaxel), a potent chemotherapeutic drug, is widely used in the treatment of various cancers, but its clinical efficacy is often limited by poor water solubility, toxic side effects, and rapid metabolism. Nanoparticles, such as liposomes, polymeric nanoparticles, and micelles, have been developed to encapsulate Taxol and improve its therapeutic properties. The synthesis of Taxol-loaded nanoparticles involves various methods, including chemical and physical techniques such as solvent evaporation, co-precipitation, and electrospinning, which allow for precise control over the size, surface charge, and drug release profile. Liposomal formulations of Taxol have shown significant improvements in tumor-targeted drug delivery and reduced systemic toxicity. Additionally, polymeric nanoparticles and micelles can provide sustained and controlled release of Taxol, enhancing its anticancer effects while minimizing side effects. Surface functionalization of these nanoparticles with targeting ligands further improves their specificity towards cancer cells, making them ideal candidates for personalized cancer therapy. The combination of nanoparticle technology with Taxol holds great promise in overcoming the limitations of traditional chemotherapy, offering a more effective and less toxic treatment option for cancer patients.

کلیدواژه ها:

Taxol ، Paclitaxel ، Nanoparticles ، Cancer therapy ، Drug delivery ، Liposomes ، Polymeric nanoparticles