Effect of vitamin D supplementation on inflammatorybiomarkers in children and adolescents: a systematic reviewand meta-analysis of randomized clinical trials

Purpose: This Numerous clinical trials have examined the beneficial effects of vitamin D supplementation inchildren and adolescents; however, the results of these studies are inconsistent. Therefore, we conducted thecurrent systematic review and meta-analysis to evaluate the effect of vitamin D supplementation oninflammatory biomarkers in children and adolescents.Methods: Databases including PubMed, Cochrane Library, Embase databases, Scopus, and Google Scholarwere searched by two reviewers independently up to April ۲۰۲۳ for RCTs investigating the effect of vitaminD supplementation on inflammatory biomarkers in children and adolescents. Data were pooled usingrandom-efects meta-analysis and presented as standardised mean diference (Hedges g) with ۹۵% confdenceintervals (۹۵% CI). Subgroup analysis was performed to investigate the efects of duration of supplementationand total dosage of vitamin D, age and weight.Results: Totally, ۸۵۸ participants were enrolled in our meta-analysis and ۵ to ۱۸ years of age. vitamin Dsupplementation wasn't associated with signifcant reductions in CRP [WMD: -۰.۱۴ mg/dl, ۹۵%CI: -۰.۵۳to۰.۲۴, P=۰.۴۶۵], IL-۶ [WMD: ۰.۲۷, ۹۵%CI: -۰.۰۷to۰.۶۱, P=۰.۱۲۵], IL-۱۰ (WMD: ۰.۶, ۹۵%CI: -۰.۲۹to۰.۱۴۸, P=۰.۱۸۶] and TNF [WMD: -۱.۵۰, ۹۵% CI: -۱.۵۸to۰.۵۶, P=۰.۳۴۶]. Subgroup analysis based onindicated that the overweight and obesity of the participants in the intervention could explain a reason forthe heterogeneity (I۲=۰.۰%, P=۰.۴۳۴),so that, the effect of vitamin D supplementation on CRP wassignificant for studies in which participants were obese or overweight [WMD: -۰.۶۲mg/dl, ۹۵%CI: ۰.۷۶to-۰.۴۸, P<۰.۰۰۱].Conclusions: The current finding did not show statistically significant impact of vitamin D supplementationon selected proinflammatory cytokines (IL-۶, IL-۱۰ and TNF-α) and C-reactive protein in children andadolescents.

کلیدواژه ها:

Vitamin D ، Inflammatory biomarkers ، Children and adolescents ، Meta-analysis