MAGHEMITE-NANOPARTICLES IN CARBON PASTE ELECTRODE STUDY OF THE ENHANCED EFFECT FOR AN ANTI-OXIDANT DRUG DETERMINATION UTILIZING SIMULTANEOUS STATISTICAL BASED EXPERIMENTAL DESIGN OPTIMIZATION

The novel significant effect of maghemite (γ-Fe2O3) nanoparticles on the behavior of voltammetric carbon paste electrode for possible bio determinationwas studied. The electrochemical performance of maghemite NPs modified carbon paste electrode (MMCPE) was investigated by using cyclicvoltammetry (CV) and differential pulse voltammetry (DPV) compared to those of unmodified ones. The different parameters affecting the response wereoptimized utilizing simultaneous statistical based experimental design. Results indicate that MMCPE can remarkably enhance electrocatalytic activitytoward the oxidation of dipyridamole (DIP) in pH 2.0 Britton−Robinson buffer solution. Under optimal conditions a detection limit of 5.0×10-9 mol L−1 (2.5ng mL−1) by DPV was obtained. The highly advantageous method were then tested for the electrochemical bio sensing applications throughsimple, rapid and sensitive determination of DIP in pharmaceutical formulations and human plasma as real samples.