A brief review on the application of atomic microscope in cellular and molecular biology sciences

The basic principle of the atomic force microscope (AFM) enables the ability to accurately measure very small materials, so it is much more than a high-resolution microscope capable of recording the fine ultrastructural details of cellular surfaces; The liquid atomic force microscope is a type of scanning probe microscope that is used as an inverted optical microscope. Among its unique features, we can mention the presence of microscopic channels in the probe of the atomic force microscope. These channels are smaller pores. of ۳۰۰ nm, these channels make it possible to examine the volume of liquid on a femtoliter scale, and this practice is useful in addition to cellular and molecular biology, but it will also be useful in material science and chemistry.