The Association of PRODH Gene Polymorphism P۱۹Q and the risk of Schizophrenia in the Iranian Patients

Abstract Background: ۲۲q۱۱.۲ deletion is a common microdeletion, and about ۳۰% of patients with ۲۲q۱۱.۲ deletion develop schizophrenia. PRODH is one of the genes located in ۲۲q۱۱.۲ and encodes the proline oxidase enzyme (POX) in the mitochondrial inner membrane and is expressed in the skin, liver, kidney, and brain. The PRODH gene's polymorphisms in increasing the risk of getting afflicted with schizophrenia have been demonstrated in previous Linkage and Association studies. Proline dehydrogenase enzyme (POX) 's role is to catalyze proline's conversion into glutamate. Reduced enzyme leads to increased proline and decreased glutamate and resulting in hyperprolinemia. It has been proven that P۱۹Q mutation in PRODH declines pox enzyme activity and is associated with schizophrenia disorder.  Objectives: In the present study, the rs۲۰۰۸۷۲۰ variant in the PRODH gene was genotyped in ۱۰۰ schizophrenic patients whose diseases were confirmed by experts and in ۱۰۰ healthy people without any history of schizophrenia and bipolar disorder in their pedigree.  Methods: To identify this variant, the PCR-RFLP technique has been adopted. The association of mutant and normal variants between the two groups afflicted with the disease and non-afflicted with the disease has been analyzed by SPSS ۱۶ software.  Results: According to our results, we found no association between P۱۹Q missense mutation and schizophrenia disorder in Iranian patients. So the P۱۹Q missense mutation could not be considered co-related with the increasing risk of schizophrenia in Iranian patients.

کلیدواژه ها:

Schizophrenia ، Single Nucleotide Polymorphism ، Proline Dehydrogenase