Synthesis of ۲-aryl -۳H-indol-۳-ones via oxygenation of ۲-aryl indoles with molecularoxygen

We describe the synthesis of ۲-aryl-۳H-indol-۳-ones via oxygenation of ۲-aryl indoles with molecularoxygen as the oxidant and oxygen source. Under an atmosphere of O۲ (۱ atm) or air (۱ atm), successfullyincorporated one O atom from O۲ into ۲-aryl indoles by copper/۲,۲,۶,۶-tetramethylpiperidine (TEMP)-catalyzed.The high efficiency, low cost, high oxygen atom economy, and practical operation make the developedoxygenation system very attractive and practical. The advantages of this method include mild reactionconditions, simple procedures, and easy workup

کلیدواژه ها:

۲-Aryl indoles ، ۲-Aryl -۳H-indol-۳-ones ، Environmental reaction ، Oxygenation