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مقالات فارسیISIکنفرانسهاژورنالها

۳, ۴-dihydropyrimidin-۲(۱H)-ones: Synthesis, anticancer activity evaluation, and Molecularmodeling studies

محل انتشار: بیست و دومین کنگره بین المللی شیمی انجمن شیمی ایران
سال انتشار: 1403
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 94

نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/2034209

شناسه ملی سند علمی:

NICEC22_592

تاریخ نمایه سازی: 7 مرداد 1403

چکیده مقاله:

A series derivatives of ۳, ۴-dihydropyrimidin-۲(۱H)-ones were synthesized through the Biginelli multicomponentreaction and tested for effectiveness against cancer cells. The results showed that the Compound ۵lwere more effective against A۵۴۹ cancer cells. Additionally, Molecular docking and dynamics studies wereperformed on this derivative in the active site of Eg۵ and AKT۱ enzymes.

کلیدواژه ها:

Cancer ، ۳ ، ۴-dihydropyrimidinones ، Cytotoxicity ، Molecular Modeling ، EG۵ ، AKT۱

نویسندگان

Seyyede Faeze Mortazavi

Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences,Ahvaz, Iran.b Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Ahmad Ebadi

Department of Medicinal Chemistry, School of Pharmacy, Medicinal Plants and Natural Products Research Center,Hamadan University of Medical Sciences, Hamadan, Iran.

Mahsa Toolabi

Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences,Ahvaz, Iran.b Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Mohammad Navid Mohammadian

Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences,Ahvaz, Iran.b Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Ayyub Mojaddami

Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences,Ahvaz, Iran.b Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.