Synthesis of bio-nanocomposite hydrogel beads based on sodium alginate and β-cyclodextrin with modified magnetic nanoparticles: pH-responsive oral delivery systemsfor anticancer potential in colorectal cancer

Oral drug delivery systems have attracted considerable attention because they can improve thetreatment of gastrointestinal diseases (GIT) such as colorectal cancer while reducing the side effects ofchemotherapy and improving the effectiveness of drugs. This work aims to synthesize pH-sensitive magneticbio-nanocomposite hydrogel beads based on sodium alginate (SA) and β-cyclodextrin (β-CD) polymers fordelivery of the drug doxorubicin hydrochloride (DOX) against colon cancer. This carrier contains silvernanoparticles (Ag-NPs) reduced and Fe۳O۴ nanoparticles (MNPs). The successful synthesis was verified andconfirmed by various analytical methods using FTIR, XRD, SEM, VSM, and TGA analysis. Bio-nanocompositehydrogel beads prepared at different simulated pH values of the digestive system (۱.۲, ۶.۸, and ۷.۴) were studiedand showed pH-sensitive swelling behavior.

کلیدواژه ها:

Bio-nanocomposite hydrogel beads ، β-cyclodextrin ، pH-responsive ، doxorubicin ، drug delivery