A Novel Zn(II) Complex of N–Nicotinyl-N, Nʺ-bis (Piperidinyl) phosphoric triamide, andInvestigating its anticancer activity

A new Zn(II) complex (CZ) containing Phosphoramide ligand (L) with a formula of ZnCl۲(L)۲(CZ)successfully synthesized which L= ۳-NC۵H۴CONHPO(NC۵H۱۰)۲. UV-Vis, ۳۱PNMR, FT-IR, SEM, Mass, CHN, and Molarconductivity methods were utilized to characterize CZ. Cytotoxic activity was investigated against two cancercell lines (MDA-MB-۲۳۱, MCF-۷) and one normal cell line (MCF۱۰A) and showed better and more selectiveanticancer activity compared to Cisplatin.

کلیدواژه ها:

Zinc (II) Complex ، Phosphoramide ، Anticancer ، Cisplatin