Comparison of Antibiotic Susceptibility of Klebsiella Species Causing ‎Urinary Tract Infection in Iran and Other Countries around Asia ‎

This study aimed to evaluate the antibiotic-susceptibility pattern of Klebsiella pneumoniae causing urinary tract infection (UTI) in two geographical regions of Iran and then compare it to the rest of Iran and other countries. Over a year, from winter ۲۰۱۴ to winter ۲۰۱۵, ۸۰ cases of Klebsiella were isolated from ۲۵۸۴ urine samples and identified using biochemical and microbiological tests. The disk diffusion method was used to determine antibiotic susceptibility based on the standard protocols provided by the CLSIs. The results of this study were compared with several reports from Iran and other countries, before the COVID-۱۹ pandemic from ۲۰۰۷ to ۲۰۱۸. Based on the results of the antibiotic susceptibility of ۸۰ isolated K. pneumoniae, amikacin (AN), Meropenem (MEN), gentamicin (GM), and ciprofloxacin (CP) were identified as the most sensitive antibiotics with ۷۷.۵%, ۷۷%, ۷۵%, and ۵۸.۷۵% sensitivity, respectively. A comparison of ۱۷ report results showed imipenem (IPM) is the most sensitive antibiotic against the K. pneumoniae isolates, with a sensitivity range of ۸۵% -۱۰۰%. Followed by amikacin (AN), which was reported as the first or second antibiotic or third or fourth antibiotic in less than ۳۰% of the cases. CP was reported as a second or third option in ۲۲% of the cases. This study evaluated the sensitivity pattern of K. pneumoniae to antibiotics, and the results show that it has the potential to be applied to further studies and related programs, including periodic screening, regional screening, and revision in therapeutic approaches.

کلیدواژه ها:

Urinary tract infections ، Enterobacteriaceae ، Klebsiella ، Antibiotic ‎ resistance ، public health threat.&lrm