Three-Component Synthesis of Bis(indolyl)methane with Sulfanilic Acid as an Efficient Catalyst

The biological activities and therapeutic qualities of indoles as well as their derivatives have garnered significant attention. I n this study, the solid acidic organocatalyst (sulfanilic acid) was examined for the synthesis of derivatives of bis(indolyl)methanes (BIMs) at ambient temperature and in water and ethanol as solvent. BIMs was prepared and characterized by appearance, TLC, FT-IR, and melting point and were further supported by CHNS analysis. The approach has a lot of advantages, including a clean reaction, operational simplicity, a simple experimental work-up process, waste minimization, non-toxicity, quicker reaction times, and high yields of the compounds.

کلیدواژه ها:

sulfanilic acid ، Organocatalyst ، Bis(indolyl)methanes