A review on the herbal medicines on wound repair through TGF-beta and bFGF

In the process of wound healing, two factors including transforming-growth factor β۱ (TGFβ۱) and basicfibroblast growth factor (bFGF) play a key role. There are two therapeutic approaches to wound repairconsisting of beauty wise and strength wise. This study was performed to review the roles herbal medicines inwound repair process focusing on the role of TGFβ۱ and bFGF according to approaches. Scientific databasesincluding Google Scholar, PubMed, Web of Science and Scopus were used to search for review articles aboutusing herbal medicines in wound repair. Wound repair is a very complex process. Consequently, management ofwound should be interdisciplinary and using herbal medicines is of a great importance. Targeting different partsof this complex mechanism may have different clinical results. Medicinal plants are not exceptions and they mayhave different outcomes. Management strategy of wound depends on many factors. Clinical studies are neededto resolve the controversies in future.

کلیدواژه ها:

wound repair ، herbal medicine ، biological systems