Investigating the Ability of Radiomics Features for Diagnosis of the Active Plaque of Multiple Sclerosis Patients

Background: Multiple sclerosis (MS) is the most common non-traumatic disabling disease.Objective: The aim of this study is to investigate the ability of radiomics features for diagnosing active plaques in patients with MS from T۲ Fluid Attenuated Inversion Recovery (FLAIR) images.Material and Methods: In this experimental study, images of ۸۲ patients with ۱۲۲ MS lesions were investigated. Boruta and Relief algorithms were used for feature selection on the train data set (۷۰%). Four different classifier algorithms, including Multi-Layer Perceptron (MLP), Gradient Boosting (GB), Decision Tree (DT), and Extreme Gradient Boosting (XGB) were used as classifiers for modeling. Finally, Performance metrics were obtained on the test data set (۳۰%) with ۱۰۰۰ bootstrap and ۹۵% confidence intervals (۹۵% CIs).Results: A total of ۱۰۷ radiomics features were extracted for each lesion, of which ۷ and ۸ features were selected by the Relief method and Boruta method, respectively. DT classifier had the best performance in the two feature selection algorithms. The best performance on the test data set was related to Boruta-DT with an average accuracy of ۰.۸۶, sensitivity of ۱.۰۰, specificity of ۰.۸۴, and Area Under the Curve (AUC) of ۰.۹۲ (۹۵% CI: ۰.۹۲-۰.۹۲). Conclusion: Radiomics features have the potential for diagnosing MS active plaque by T۲ FLAIR image features. Additionally, choosing the feature selection and classifier algorithms plays an important role in the diagnosis of active plaque in MS patients. The radiomics-based predictive models predict active lesions accurately and non-invasively.

کلیدواژه ها:

Multiple Sclerosis ، Machine Learning ، Magnetic Resonance Imaging ، Radiomics ، FLAIR